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JWH-018 (1-pentyl-3-(1-naphthoyl)indole), also known as AM-678, is a potent synthetic cannabinoid that acts as a full agonist at the CB1 and CB2 receptors. Originally synthesized by Dr. John W. Huffman, it is widely used in chemical and pharmacological research to study the endocannabinoid system and the psychoactive effects of cannabinoid receptor activation.

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